Non sedating antihistamine safe in pregnancy

Acetaminophen, which is used by about 65% of pregnant women, is generally considered safe during any trimester.Cold medications are also commonly used and are considered safe for short-term use outside of the first trimester.Fexofenadine is a metabolite of terfenadine, which was removed from the market in 1998 because of a risk of cardiotoxicity.

Either animal-reproduction studies have not demonstrated a fetal risk but there are no controlled studies in pregnant women, or animal-reproduction studies have shown an adverse effect (other than a decrease in fertility) that was not confirmed in controlled studies in women in the first trimester (and there is no evidence of a risk in later trimesters).Nonsteroidal anti-inflammatory drugs are generally not recommended in pregnancy, especially during organogenesis and in the third trimester.There is even fewer data regarding use of individual herbal supplements.All OTC medication use should be discussed with patients, and the effects of the symptoms should be balanced with the risks and benefits of each medication.Because of the expanding OTC market, formalized studies are warranted for patients to make a safe and informed decision about OTC medication use during pregnancy.

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